ILONA KARIV
Director,
Automated Lead Optimization

Ilona Kariv graduated from Pennsylvania State University with her Ph.D. in immunogenetics.  After completing her postdoctoral training at Fox Chase Cancer Center and at SmithKline Beecham Pharmaceuticals in cellular and molecular immunology, she joined Dupont Pharmaceuticals where she was involved in high throughput screening, miniaturization and lead optimization.

Dr. Kariv joined Merck in 2004 where she continues to focus on the areas of assay development and novel technologies adapted to screening and lead optimization processes.

Key Publications, 2003 – Present
Wang MM, Schnabel CA, Chachisvilis M, Yang R, Paliotti MJ, Simons LA, McMullin L, Hagen N, Lykstad K, Tu E, Pestana LM, Sur S, Zhang H, Butler WF, Kariv I, Marchand PJ.
Optical forces for noninvasive cellular analysis. Appl Opt. 2003 Oct 1;42(28):5765-73.

Forster AH, Wang MM, Butler WF, Chachisvilis M, Chung TD, Esener SC, Hall JM, Kibar O,Lykstad K, Marchand PJ, Mercer EM, Pestana LM, Sur S, Tu E, Yang R, Zhang H, Kariv I.
Use of moving optical gradient fields for analysis of apoptotic cellular responses in a chronic myeloid leukemia cell model. Anal Biochem. 2004 Apr 1;327(1):14-22.

Wang MM, Tu E, Raymond DE, Yang JM, Zhang H, Hagen N, Dees B, Mercer EM, Forster AH, Kariv I, Marchand PJ, Butler WF.
Microfluidic sorting of mammalian cells by optical force switching. Nat Biotechnol. 2005 Jan;23(1):83-7.